Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Autophagy is triggered in vascular smooth muscle cells (VSMCs) of diseased arterial
vessels. However, the role of VSMC autophagy in cardiovascular disease is poorly …

Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

Rationale: Activation of NLRP3 (nucleotide-binding domain and leucine-rich repeat pyrin
domain containing 3) inflammasome-mediating interleukin (IL)-1β secretion has emerged as …

Oxidative stress is generated by the imbalance between reactive oxygen species (ROS)
formation and antioxidant scavenger system's activity. Increased ROS, such as superoxide …

Mitophagy is an evolutionarily conserved process to selectively remove damaged or
unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent …

Atherosclerosis is a multifactorial chronic and inflammatory disease of medium and large
arteries, and the major cause of cardiovascular morbidity and mortality worldwide. The …

BACKGROUND: Diabetes is a major risk factor for atherosclerotic cardiovascular diseases
with a 2-fold higher risk of cardiovascular events in people with diabetes compared with …

The volume of publications on the role of reactive oxygen species (ROS) in biological
processes has been increasing exponentially over the last decades. ROS in large amounts …