Von Willebrand factor (VWF) is a large and complex plasma glycoprotein that is essential for
normal haemostasis. It is well recognized that deficiency of VWF results in a bleeding …

The process of haemostasis is complex and is further complicated in the parturient because
of the physiological changes of pregnancy. Understanding these changes and the impact …

Hemophilia is a rare disorder that is complex to diagnose and to manage. These evidence‐
based guidelines offer practical recommendations on the diagnosis and general …

The article discusses the guidelines of the United Kingdom Haemophilia Centre Doctors'
Organization (UKHCDO) related to the diagnosis and management of patients with rare …

von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder
affecting both males and females, causing mucous membrane and skin bleeding symptoms …

Postpartum haemorrhage (PPH) is a major risk factor for maternal morbidity and mortality.
PPH has numerous causative factors, which makes its occurrence and severity difficult to …

The deficiency of fibrinogen, prothrombin, factor V (FV), FVII, FVIII, FIX, FX, FXI, and FXIII,
called rare coagulation disorders (RCDs), may result in coagulopathies leading to …

Hemophilia is a bleeding disorder with X-linked inheritance. Current prenatal diagnostic
methods for hemophilia are invasive and pose a risk to the fetus. Cell-free fetal DNA …

The coagulation system undergoes significant change during pregnancy. The clinician
caring for the parturient must understand these changes, particularly when the parturient has …

Objective Reference values are usually defined based on blood samples from healthy men
or nonpregnant women. This is not optimal as many biological markers changes during …