The two sides of the covid-19 pandemic

R Kumar, V Srivastava, KN Nand - COVID, 2023 - mdpi.com
On 5 May 2023, the World Health Organization (WHO) officially declared the end of the
coronavirus disease-19 (or COVID-19) pandemic. Even before the official announcement …

Human genomics of COVID-19 pneumonia: Contributions of rare and common variants

A Cobat, Q Zhang… - Annual review of …, 2023 - annualreviews.org
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

P Bastard, A Gervais, M Taniguchi, L Saare… - Journal of Experimental …, 2024 - rupress.org
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …

Struggling with Covid-19 in adult inborn errors of immunity patients: A case series of combination therapy and multiple lines of therapy for selected patients

P Bez, G D'ippolito, CM Deiana, R Finco Gambier… - Life, 2023 - mdpi.com
Background: The SARS-CoV-2 infection is now a part of the everyday lives of
immunocompromised patients, but the choice of treatment and the time of viral clearance …

Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals

OM Delmonte, C Oguz, K Dobbs, K Myint-Hpu… - Journal of Allergy and …, 2024 - Elsevier
Background Functional T-cell responses are essential for virus clearance and long-term
protection after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Fatal COVID-19 Infection in Two Children with STAT1 Gain-of-Function

AT Staines-Boone, P Vignesh, M Tsumura… - Journal of Clinical …, 2024 - Springer
While SARS-CoV-2 infection causes a mild disease in most children, SARS-CoV-2 infection
may be lethal in a few of them. In the defense against SARS-CoV-2, type I interferons are …

Molecular determinants of cross-species transmission in emerging viral infections

A Wickenhagen, S van Tol… - … and Molecular Biology …, 2024 - journals.asm.org
Several examples of high-impact cross-species transmission of newly emerging or re-
emerging bat-borne viruses, such as Sudan virus, Nipah virus, and severe acute respiratory …

Cellular immunity in COVID-19 and other infections in Common variable immunodeficiency

RØ Løken, B Fevang - Frontiers in Immunology, 2023 - frontiersin.org
COVID-19 has shed light on the role of cellular immunity in the absence of humoral
response in different patient groups. Common variable immunodeficiency (CVID) is …

What has vaccination against COVID-19 in CKD patients taught us?

M Rossi, G Pessolano, G Gambaro - Journal of Nephrology, 2023 - Springer
Effective vaccination strategies are of crucial importance to protecting patients who are
vulnerable to infections, such as patients with chronic kidney disease. This is because the …

COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19: a USIDNET Report

J McDonnell, K Cousins, MEM Younger, A Lane… - Journal of clinical …, 2024 - Springer
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients
with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, and …