Targeting autophagy using natural compounds for cancer prevention and therapy

S Deng, MK Shanmugam, AP Kumar, CT Yap, G Sethi… - Cancer, 2019 - Wiley Online Library
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the
stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation …

Potential therapeutic targets of resveratrol, a plant polyphenol, and its role in the therapy of various types of cancer

SA Almatroodi, M A. Alsahli, A SM Aljohani… - Molecules, 2022 - mdpi.com
Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy
modes employed, including chemotherapy and radiotherapy, have been reported to be …

Modulation of autophagy in cancer cells by dietary polyphenols

C Musial, K Siedlecka-Kroplewska, Z Kmiec… - Antioxidants, 2021 - mdpi.com
The role of autophagy is to degrade damaged or unnecessary cellular structures. Both in
vivo and in vitro studies suggest a dual role of autophagy in cancer—it may promote the …

Molecular insights into the multifunctional role of natural compounds: autophagy modulation and cancer prevention

MA Rahman, MDH Rahman, MS Hossain, P Biswas… - Biomedicines, 2020 - mdpi.com
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein
molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress …

Polyphenols and their metabolites in renal diseases: An overview

Í Guerreiro, C Ferreira-Pêgo, D Carregosa, CN Santos… - Foods, 2022 - mdpi.com
Kidney diseases constitute a worldwide public health problem, contributing to morbidity and
mortality. The present study aimed to provide an overview of the published data regarding …

Resveratrol as an enhancer of apoptosis in cancer: a mechanistic review

M Ashrafizadeh, S Taeb… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
The resistance to therapy of cancer cells is a challenge for achieving an appropriate
therapeutic outcome. Cancer (stem) cells possess several mechanisms for increasing their …

Plant-derived medicines for treatment of endometriosis: A comprehensive review of molecular mechanisms

F Bina, S Soleymani, T Toliat, M Hajimahmoodi… - Pharmacological …, 2019 - Elsevier
Endometriosis is an estrogen-dependent disease with inflammatory lesions at extra-uterine
sites, causing pelvic pain and fertility reduction. Conventional therapies primarily focus on …

Novel approaches of dysregulating lysosome functions in cancer cells by specific drugs and its nanoformulations: a smart approach of modern therapeutics

KS Allemailem, A Almatroudi, F Alrumaihi… - International journal …, 2021 - Taylor & Francis
The smart strategy of cancer cells to bypass the caspase-dependent apoptotic pathway has
led to the discovery of novel anti-cancer approaches including the targeting of lysosomes …

Phytochemicals for the prevention and treatment of renal cell carcinoma: preclinical and clinical evidence and molecular mechanisms

EM Bajalia, FB Azzouz, DA Chism, DM Giansiracusa… - Cancers, 2022 - mdpi.com
Simple Summary Renal cell carcinoma (RCC) is the most frequently diagnosed kidney
cancer. Once RCC metastasizes, successful treatment is difficult to achieve. There is an …

Resveratrol induces apoptosis and attenuates proliferation of MCF-7 cells in combination with radiation and hyperthermia

P Amini, SJ Nodooshan, M Ashrafizadeh… - Current molecular …, 2021 - ingentaconnect.com
Aim: In the current in vitro study, we tried to examine the possible role of resveratrol as a
sensitizer in combination with radiotherapy or hyperthermia. Background: Breast cancer is …