Alginate biomaterial is widely utilized for tissue engineering and regeneration due to its
biocompatibility, non-thrombogenic nature, mild and physical gelation process, and the …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Understanding the mechanisms by which adult stem cells produce growth factors may
represent an important way to optimize their beneficial paracrine and autocrine effects …

Recent studies suggest that the main driving force behind the therapeutic activity observed
in mesenchymal stem cells (MSCs) are the paracrine factors secreted by these cells. These …

Human pluripotent stem cell-derived cardiomyocytes (CMs) are a promising tool for cardiac
cell therapy. Although transplantation of induced pluripotent stem cell (iPSC)-derived CMs …

With the goal of devising a non-invasive cell therapy for cardiac repair that may be well
tolerated by patients with myocardial infarction (MI), this study evaluated the efficacy of …

Myocardial infarction rapidly depletes the endogenous cardiac progenitor cell pool, and the
inefficient recruitment of exogenously administered progenitor cells limits the effectiveness …

The recruitment of bone marrow CD34− mesenchymal stem‐and progenitor cells (MSC) and
their subsequent differentiation into distinct tissues is the precondition for in situ tissue …

Myocardial infarction triggers an inflammatory cascade that results in healing and
replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate …

Myocardial infarction is associated with persistent muscle damage, scar formation and
depressed cardiac performance. Recent studies have demonstrated the clinical significance …