Calcium is an important second messenger involved in intra-and extracellular signaling
cascades and plays an essential role in cell life and death decisions. The Ca 2+ signaling …

Cholesterol/sphingolipid-rich membrane domains, known as lipid rafts or membrane rafts,
play a critical role in the compartmentalization of signaling pathways. Physical segregation …

The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients, thus causing
the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to …

Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

Cholesterol is a lipid molecule that plays an essential role in a number of biological
processes, both physiological and pathological. It is an essential structural constituent of cell …

Lipid rafts are cholesterol‐and sphingolipid‐enriched specialized membrane domains within
the plasma membrane. Lipid rafts regulate the density and activity of signal receptors by …

Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that
sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts …

Lipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol
content involved in diverse cellular processes. They have been proposed to influence …

Introduction. Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease (AD). With the ageing of population, the frequency of PD is …

Background Leishmaniasis is the world's second deadliest parasitic disease after malaria,
and current treatment of the different forms of this disease is far from satisfactory …