Abstract Non-enzymatic chitinase-3 like-protein-1 (CHI3L1) belongs to glycoside hydrolase
family 18. It binds to chitin, heparin, and hyaluronic acid, and is regulated by extracellular …

Background. In cancer cells, metabolism is shifted to aerobic glycolysis with lactate
production coupled with a higher uptake of glucose as the main energy source. Lactate …

Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over
species and time and are dysregulated in inflammatory, infectious, remodeling, and …

The use of biomarkers in medicine has become essential in clinical practice in order to help
with diagnosis, prognostication and prediction of treatment response. Since Alexander …

Tumor angiogenesis is of paramount importance in solid tumor development. Elevated
serum levels of YKL-40, which is a secreted heparin-binding glycoprotein, have been …

Evasion of the immune response is a hallmark of cancer, and programmed cell death 1 (PD-
1) and PD-1 ligand 1 (PD-L1) are major mediators of this immunosuppression. Chitinase 3 …

YKL-40, a member of the “mammalian chitinase–like proteins,” is expressed and secreted by
several types of solid tumors. The exact function of YKL-40 in cancer diseases is unknown …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Substantial evidence supports a role of chronic subclinical inflammation and activation of the
innate immune system in the pathogenesis of insulin resistance and endothelial dysfunction …

Human Glyco_18 domain-containing proteins constitute a family of chitinases and chitinase-
like proteins. Chitotriosidase and AMCase are true enzymes which hydrolyse chitin and …