The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

The autosomal dominant cerebellar ataxias (ADCAs) represent a heterogeneous group of
neurodegenerative diseases with progressive ataxia and cerebellar degeneration. The …

The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …

Maintaining the functional integrity of mitochondria is pivotal for cellular survival. It appears
that neuronal homeostasis depends on high-fidelity mitochondria, in particular …

An impairment of eye movements, or nystagmus, is seen in many diseases of the central
nervous system, in particular those affecting the brainstem and cerebellum, as well as in …

Abstract Background All spinocerebellar ataxias (SCAs) are rare diseases. SCA1, 2, 3 and 6
are the four most common SCAs, all caused by expanded polyglutamine-coding CAG …

Significance: Once considered to be mere by-products of metabolism, reactive oxygen,
nitrogen and sulfur species are now recognized to play important roles in diverse cellular …

Recent research indicates that physiotherapy can improve motor performance of patients
with cerebellar degeneration. Given the known contributions of the cerebellum to motor …

Cerebellar ataxias (CAs) comprise a group of rare, neurological disorders characterized by
extensive phenotypic and genetic heterogeneity. The core clinical feature is the cerebellar …

Background: Ocular motor abnormalities reflect the varied neuropathology of
spinocerebellar ataxias (SCAs) and may serve to clinically distinguish the different SCAs …