Targeting RNA structures with small molecules
JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
Targeting RNA with small molecules: from fundamental principles towards the clinic
Recent advances in our understanding of RNA biology have uncovered crucial roles for
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …
RNA in multiple disease states, ranging from viral and bacterial infections to cancer and …
[HTML][HTML] Programming inactive RNA-binding small molecules into bioactive degraders
Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …
compounded by the longstanding challenges surrounding the molecular recognition of RNA …
How we think about targeting RNA with small molecules
MG Costales, JL Childs-Disney, HS Haniff… - Journal of medicinal …, 2020 - ACS Publications
RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space
NF Rizvi, JP Santa Maria Jr, A Nahvi… - … the Science of Drug …, 2020 - journals.sagepub.com
Although the potential value of RNA as a target for new small molecule therapeutics is
becoming increasingly credible, the physicochemical properties required for small …
becoming increasingly credible, the physicochemical properties required for small …
Small molecule–RNA targeting: starting with the fundamentals
AE Hargrove - Chemical Communications, 2020 - pubs.rsc.org
The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
opportunities for targeting by small molecules, yet fundamental understanding of what drives …
96-well microtiter plate made of paper: a printed chemosensor array for quantitative detection of saccharides
Simple, rapid, and accurate detection methods for saccharides are potentially applicable to
various fields such as clinical and food chemistry. However, the practical applications of on …
various fields such as clinical and food chemistry. However, the practical applications of on …
Regulation of MALAT1 triple helix stability and in vitro degradation by diphenylfurans
A Donlic, M Zafferani, G Padroni, M Puri… - Nucleic acids …, 2020 - academic.oup.com
Small molecule-based modulation of a triple helix in the long non-coding RNA metastasis-
associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive …
associated lung adenocarcinoma transcript 1 (MALAT1) has been proposed as an attractive …
Indicator displacement assays: from concept to recent developments
Overcoming the synthetic burden related to covalently connected receptors with appropriate
indicators for sensing various analytes via an indicator spacer receptor (ISR) approach, the …
indicators for sensing various analytes via an indicator spacer receptor (ISR) approach, the …
Discovery of RNA-targeted small molecules through the merging of experimental and computational technologies
EC Morishita - Expert Opinion on Drug Discovery, 2023 - Taylor & Francis
Introduction The field of RNA-targeted small molecules is rapidly evolving, owing to the
advances in experimental and computational technologies. With the identification of several …
advances in experimental and computational technologies. With the identification of several …