The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

Bile acids are cholesterol-derived surfactants that circulate actively between the liver and
ileum and that are classically recognized for emulsifying dietary lipids to facilitate absorption …

The microbiome plays a key role in health and disease, and there has been considerable
interest in therapeutic targeting of the microbiome as well as mining this rich resource in …

Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Over the past decade, the gut microbiota has received considerable attention for its
interactions with the host. Microbial β-glucuronidase generated by this community has …

Anthocyanins, the natural red and purple colorants of berries, fruits, vegetables, and tubers,
improve carbohydrate metabolism and decrease the risk factors of metabolic disorders, but …