The infectious microscopic viruses invade living cells to reproduce themselves, and causes
chronic infections such as HIV/AIDS, hepatitis B and C, flu, etc. in humans which may lead to …

The properties of benzimidazole and its derivatives have been studied over more than one
hundred years. Benzimidazole derivatives are useful intermediates/subunits for the …

The study of human cytomegalovirus (HCMV) antiviral drug resistance has enhanced
knowledge of the virological targets and the mechanisms of antiviral activity. The currently …

Viruses rely on the metabolic network of the host cell to provide energy and macromolecular
precursors to fuel viral replication. Here we used mass spectrometry to examine the impact …

In the setting of intensive immunosuppression for the management of rejection in solid organ
transplant (SOT) recipients, or graft-versus-host disease (GVHD) in hematopoietic stem cell …

Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Background and aims Perinatal cytomegalovirus (CMV) infection is a possible cause or
trigger of biliary atresia though clinical evidence is scant. We hypothesised that CMV IgM+ …

Following the discovery of the first effective antiviral compound (idoxuridine) in 1959,
nucleoside analogues, especially acyclovir (ACV) for the treatment of herpesvirus infections …

Benzimidazole nucleosides have been shown to be potent inhibitors of human
cytomegalovirus (HCMV) replication in vitro. As part of the exploration of structure-activity …

CDC, the Infectious Diseases Society of America, and the American Society of Blood and
Marrow Transplantation have cosponsored these guidelines for preventing opportunistic …