Spectrum matching is the most common method for compound identification in mass
spectrometry (MS). However, some challenges limit its efficiency, including the coverage of …

Direct diagnosis and accurate assessment of metabolic syndrome (MetS) allow for prompt
clinical interventions. However, traditional diagnostic strategies overlook the complex …

COVID-19 caused by SARS-CoV-2 has continually been serious threat to public health
worldwide. While a few anti-SARS-CoV-2 therapeutics are currently available, their antiviral …

Metabolomics is a discipline aiming to characterize the presence of metabolites in biological
matrices under specific conditions. In recent years, metabolomics has increasingly been …

Single-cell sequencing has recently allowed the generation of exhaustive root cell atlases.
However, some cell types are elusive and remain underrepresented. Here we use a second …

This year marks the 25th anniversary of the coinage of the term metabolome [SG Oliver et
al., Trends Biotech. 16, 373–378 (1998)]. As the field rapidly advances, it is important to take …

Background Fresh and processed fruits and vegetables (F&V) contain small molecules,
which contribute to the nutritional, taste, aroma, color, and safety quality of fresh and …

The health benefits of whole wheat consumption can be partially attributed to wheat's
phytochemicals, including phenolic acids, flavonoids, alkylresorcinols, carotenoids …

Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

Background Untargeted metabolomics approaches based on mass spectrometry obtain
comprehensive profiles of complex biological samples. However, on average only 10% of …