Paediatric autoimmune liver disease is characterized by inflammatory liver histology,
circulating autoantibodies, and increased levels of IgG, in the absence of a known etiology …

There are limited data on the natural history of primary sclerosing cholangitis (PSC) in
children. We aimed to describe the disease characteristics and long‐term outcomes of …

Autoimmune liver disease in pediatrics encompasses autoimmune hepatitis (AIH),
autoimmune overlap with sclerosing cholangitis (SC), recurrence of AIH after liver …

Background and Aims Hepatocytes undergo profound metabolic rewiring when primed to
proliferate during compensatory regeneration and in hepatocellular carcinoma (HCC) …

Primary sclerosing cholangitis (PSC) is a rare disease of stricturing and destruction of the
biliary tree with a complex genetic and environmental etiology. Most patients have co …

Although patients with PSC are increasingly diagnosed at earlier stages of disease based
on asymptomatic serum liver enzyme abnormalities, at least 45% of patients PSC present …

Background and Aims Disease progression in children with primary sclerosing cholangitis
(PSC) is variable. Prognostic and risk‐stratification tools exist for adult‐onset PSC, but not …

Adverse clinical events in primary sclerosing cholangitis (PSC) happen too slowly to capture
during clinical trials. Surrogate endpoints are needed, but no such validated endpoints exist …

The intestinal microbiome has been the intense focus of recent study, but how the microbiota
affects connected organs, such as the liver, has not been fully elucidated. The microbiome …

Purpose First, to evaluate and describe the clinical and MRI progression of patients with
small duct primary sclerosing cholangitis (sdPSC), and second, to look for MRI features …