[HTML][HTML] Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
[HTML][HTML] Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …
and contribute to the development of novel diagnostic and therapeutic strategies to further …
[HTML][HTML] Targeting inflammation in atherosclerosis—from experimental insights to the clinic
O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …
inflammation from its inception to the emergence of complications. Targeting inflammatory …
Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-inflammatory behavior for chronically infected diabetic wound …
Y Wang, Y Wu, L Long, L Yang, D Fu… - … applied materials & …, 2021 - ACS Publications
Stimuli-responsive hydrogels possess unique advantages in drug delivery due to their
variable performance and status based on the external environment. In the present study, a …
variable performance and status based on the external environment. In the present study, a …
Microfluidic nanoparticles for drug delivery
Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades.
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …
Targeting the CCL2–CCR2 axis for atheroprotection
Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …
Ligand‐installed nanocarriers toward precision therapy
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …
[HTML][HTML] Regulating trained immunity with nanomedicine
Trained immunity refers to a hyperresponsive functional state of the innate immune system,
which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays …
which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays …
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice
Atherosclerotic lesional macrophages express molecules that promote plaque progression,
but lack of mechanisms to therapeutically target these molecules represents a major gap in …
but lack of mechanisms to therapeutically target these molecules represents a major gap in …
[HTML][HTML] Engineering cytokine therapeutics
J Deckers, T Anbergen, AM Hokke, A de Dreu… - Nature Reviews …, 2023 - nature.com
Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety
of immune-related disorders. However, the widespread clinical use of cytokines has been …
of immune-related disorders. However, the widespread clinical use of cytokines has been …