The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies
Animal models and behavioral paradigms are critical for elucidating the neural mechanism
involved in complex behaviors, including social cognition. Both genotype and phenotype …
involved in complex behaviors, including social cognition. Both genotype and phenotype …
The impact of early life family structure on adult social attachment, alloparental behavior, and the neuropeptide systems regulating affiliative behaviors in the …
Early social attachments lie at the heart of emotional and social development in many
mammals, including humans. In nature, monogamous prairie voles (Microtus ochrogaster) …
mammals, including humans. In nature, monogamous prairie voles (Microtus ochrogaster) …
RNAi knockdown of oxytocin receptor in the nucleus accumbens inhibits social attachment and parental care in monogamous female prairie voles
AC Keebaugh, CE Barrett, JL Laprairie… - Social …, 2015 - Taylor & Francis
Oxytocin modulates many aspects of social cognition and behaviors, including maternal
nurturing, social recognition and bonding. Natural variation in oxytocin receptor (OXTR) …
nurturing, social recognition and bonding. Natural variation in oxytocin receptor (OXTR) …
Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles
ZV Johnson, H Walum, YA Jamal, Y Xiao… - Hormones and …, 2016 - Elsevier
Oxytocin (OT) is a deeply conserved nonapeptide that acts both peripherally and centrally to
modulate reproductive physiology and sociosexual behavior across divergent taxa …
modulate reproductive physiology and sociosexual behavior across divergent taxa …
Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
Adult pair bonding involves dramatic changes in the perception and valuation of another
individual. One key change is that partners come to reliably activate the brain's reward …
individual. One key change is that partners come to reliably activate the brain's reward …
Serotonin and motherhood: From molecules to mood
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin,
in the display of maternal behaviors and reproduction-associated plasticity in the maternal …
in the display of maternal behaviors and reproduction-associated plasticity in the maternal …
Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: the CNTRICS initiative
MJ Millan, KL Bales - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Social cognition refers to processes used to monitor and interpret social signals from others,
to decipher their state of mind, emotional status and intentions, and select appropriate social …
to decipher their state of mind, emotional status and intentions, and select appropriate social …
Increasing oxytocin receptor expression in the nucleus accumbens of pre-pubertal female prairie voles enhances alloparental responsiveness and partner preference …
AC Keebaugh, LJ Young - Hormones and behavior, 2011 - Elsevier
Oxytocin receptors (OXTR) in the nucleus accumbens (NAcc) promote alloparental behavior
and partner preference formation in female prairie voles. Within the NAcc there is significant …
and partner preference formation in female prairie voles. Within the NAcc there is significant …
Comparative assessment of familiarity/novelty preferences in rodents
AK Beery, KL Shambaugh - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Sociality—ie, life in social groups—has evolved many times in rodents, and there is
considerable variation in the nature of these groups. While many species-typical behaviors …
considerable variation in the nature of these groups. While many species-typical behaviors …
Activation of μ-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles
Despite significant evidence that opioids are involved in attachment by mediating social
reward and motivation, the role of opioids in the formation of adult social attachments has …
reward and motivation, the role of opioids in the formation of adult social attachments has …