The oxytocin system in drug discovery for autism: animal models and novel therapeutic strategies

ME Modi, LJ Young - Hormones and behavior, 2012 - Elsevier
Animal models and behavioral paradigms are critical for elucidating the neural mechanism
involved in complex behaviors, including social cognition. Both genotype and phenotype …

The impact of early life family structure on adult social attachment, alloparental behavior, and the neuropeptide systems regulating affiliative behaviors in the …

TH Ahern, LJ Young - Frontiers in behavioral neuroscience, 2009 - frontiersin.org
Early social attachments lie at the heart of emotional and social development in many
mammals, including humans. In nature, monogamous prairie voles (Microtus ochrogaster) …

RNAi knockdown of oxytocin receptor in the nucleus accumbens inhibits social attachment and parental care in monogamous female prairie voles

AC Keebaugh, CE Barrett, JL Laprairie… - Social …, 2015 - Taylor & Francis
Oxytocin modulates many aspects of social cognition and behaviors, including maternal
nurturing, social recognition and bonding. Natural variation in oxytocin receptor (OXTR) …

Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles

ZV Johnson, H Walum, YA Jamal, Y Xiao… - Hormones and …, 2016 - Elsevier
Oxytocin (OT) is a deeply conserved nonapeptide that acts both peripherally and centrally to
modulate reproductive physiology and sociosexual behavior across divergent taxa …

Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles

EA Amadei, ZV Johnson, Y Jun Kwon, AC Shpiner… - Nature, 2017 - nature.com
Adult pair bonding involves dramatic changes in the perception and valuation of another
individual. One key change is that partners come to reliably activate the brain's reward …

Serotonin and motherhood: From molecules to mood

JL Pawluski, M Li, JS Lonstein - Frontiers in neuroendocrinology, 2019 - Elsevier
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin,
in the display of maternal behaviors and reproduction-associated plasticity in the maternal …

Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: the CNTRICS initiative

MJ Millan, KL Bales - Neuroscience & Biobehavioral Reviews, 2013 - Elsevier
Social cognition refers to processes used to monitor and interpret social signals from others,
to decipher their state of mind, emotional status and intentions, and select appropriate social …

Increasing oxytocin receptor expression in the nucleus accumbens of pre-pubertal female prairie voles enhances alloparental responsiveness and partner preference …

AC Keebaugh, LJ Young - Hormones and behavior, 2011 - Elsevier
Oxytocin receptors (OXTR) in the nucleus accumbens (NAcc) promote alloparental behavior
and partner preference formation in female prairie voles. Within the NAcc there is significant …

Comparative assessment of familiarity/novelty preferences in rodents

AK Beery, KL Shambaugh - Frontiers in Behavioral Neuroscience, 2021 - frontiersin.org
Sociality—ie, life in social groups—has evolved many times in rodents, and there is
considerable variation in the nature of these groups. While many species-typical behaviors …

Activation of μ-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles

JP Burkett, LL Spiegel, K Inoue, AZ Murphy… - …, 2011 - nature.com
Despite significant evidence that opioids are involved in attachment by mediating social
reward and motivation, the role of opioids in the formation of adult social attachments has …