T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune
responses to mediate inflammation and regulate other types of immune cells. Work in the …

Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …

The intestinal mucosa serves both as a conduit for the uptake of food-derived nutrients and
microbiome-derived metabolites, and as a barrier that prevents tissue invasion by …

The trillions of microorganisms in the gut microbiome have attracted much attention recently
owing to their sophisticated and widespread impacts on numerous aspects of host …

Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

RORγt is a lineage-specifying transcription factor that is expressed by immune cells that are
enriched in the gastrointestinal tract and promote immunity, inflammation and tissue …

Small intestinal villi are structural and functional units present in higher vertebrates and
uniquely adapted to nutrient absorption. Villus enterocytes are organized in transcriptional …

The autoimmune regulator (Aire), a well-defined transcriptional regulator in the thymus, is
also found in extrathymic Aire-expressing cells (eTACs) in the secondary lymphoid organs …

Innate lymphoid cells (ILCs) exert important roles in host defense, tissue repair and
inflammatory diseases. However, how ILC lineage specification is regulated remains largely …

Transcriptional regulatory networks (TRNs) provide insight into cellular behavior by
describing interactions between transcription factors (TFs) and their gene targets. The assay …