Predictive and prognostic molecular markers for cancer medicine
S Mehta, A Shelling, A Muthukaruppan… - … in medical oncology, 2010 - journals.sagepub.com
Over the last 10 years there has been an explosion of information about the molecular
biology of cancer. A challenge in oncology is to translate this information into advances in …
biology of cancer. A challenge in oncology is to translate this information into advances in …
[HTML][HTML] The importance of DNA methylation in prostate cancer development
After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …
available to interrogate it, we consider the literature surrounding DNA methylation as …
Epigenetic modifications in prostate cancer
M Sugiura, H Sato, M Kanesaka… - … Journal of Urology, 2021 - Wiley Online Library
Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …
[HTML][HTML] Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells
Advanced prostate cancers are known to acquire not only invasive capabilities but also
significant resistance to chemotherapy-induced apoptosis. To understand how microRNAs …
significant resistance to chemotherapy-induced apoptosis. To understand how microRNAs …
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression
PC Lin, YL Chiu, S Banerjee, K Park, JM Mosquera… - Cancer research, 2013 - AACR
Androgen receptor signaling plays a critical role in prostate cancer pathogenesis. Yet, the
regulation of androgen receptor signaling remains elusive. Even with stringent androgen …
regulation of androgen receptor signaling remains elusive. Even with stringent androgen …
Cancer chemoprevention by targeting the epigenome
J Huang, C Plass, C Gerhauser - Current drug targets, 2011 - ingentaconnect.com
The term “epigenetics” refers to modifications in gene expression caused by heritable, but
potentially reversible, changes in DNA methylation and chromatin structure. Given the fact …
potentially reversible, changes in DNA methylation and chromatin structure. Given the fact …
DNA methylation based biomarkers: practical considerations and applications
AH Kit, HM Nielsen, J Tost - Biochimie, 2012 - Elsevier
A biomarker is a molecular target analyzed in a qualitative or quantitative manner to detect
and diagnose the presence of a disease, to predict the outcome and the response to a …
and diagnose the presence of a disease, to predict the outcome and the response to a …
The epigenetic promise for prostate cancer diagnosis
L Van Neste, JG Herman, G Otto, JW Bigley… - The …, 2012 - Wiley Online Library
BACKGROUND Prostate cancer is the most common cancer diagnosis in men and a leading
cause of death. Improvements in disease management would have a significant impact and …
cause of death. Improvements in disease management would have a significant impact and …
[HTML][HTML] Epigenetics in prostate cancer: clinical implications
V Conteduca, J Hess, Y Yamada, SY Ku… - … andrology and urology, 2021 - ncbi.nlm.nih.gov
Epigenetic alterations, including changes in DNA methylation, histone modifications and
nucleosome remodeling, result in abnormal gene expression patterns that contribute to …
nucleosome remodeling, result in abnormal gene expression patterns that contribute to …
Hypermethylation of CpG island loci and hypomethylation of LINE‐1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features
NY Cho, BH Kim, M Choi, EJ Yoo… - The Journal of …, 2007 - Wiley Online Library
Promoter CpG island hypermethylation is an important carcinogenic event in prostate
adenocarcinoma. Regardless of tissue type, human cancers have in common both focal …
adenocarcinoma. Regardless of tissue type, human cancers have in common both focal …