Obesity and dyslipidemia
J Vekic, A Zeljkovic, A Stefanovic, Z Jelic-Ivanovic… - Metabolism, 2019 - Elsevier
Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …
Ceramides in metabolism: key lipotoxic players
B Chaurasia, SA Summers - Annual review of physiology, 2021 - annualreviews.org
The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
JB Funcke, PE Scherer - Journal of lipid research, 2019 - ASBMB
The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …
Ceramides–lipotoxic inducers of metabolic disorders
B Chaurasia, SA Summers - Trends in Endocrinology & Metabolism, 2015 - cell.com
In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel - Nature, 2014 - nature.com
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes. Progress in our
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
understanding of sphingolipid metabolism, state-of-the-art sphingolipidomic approaches …
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
PJ Meikle, SA Summers - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
Obesity-related changes in high-density lipoprotein metabolism and function
JT Stadler, G Marsche - International journal of molecular sciences, 2020 - mdpi.com
In obese individuals, atherogenic dyslipidemia is a very common and important factor in the
increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized …
increased risk of cardiovascular disease. Adiposity-associated dyslipidemia is characterized …
Metabolic messengers: ceramides
SA Summers, B Chaurasia, WL Holland - Nature metabolism, 2019 - nature.com
Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance
Dysregulated lipid metabolism and inflammation are linked to the development of insulin
resistance in obesity, and the intracellular accumulation of the sphingolipid ceramide has …
resistance in obesity, and the intracellular accumulation of the sphingolipid ceramide has …
The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc
The contribution of mitochondria to the metabolic function of hypoxic NP cells has been
overlooked. We have shown that NP cells contain networked mitochondria and that …
overlooked. We have shown that NP cells contain networked mitochondria and that …