Background Cancer cells are characterized by uncontrolled cell proliferation and impaired
bioenergetics. Sirtuins are a family of highly conserved enzymes that play a fundamental …

Background Doxorubicin (DOX) is a widely utilized anthracycline chemotherapy drug in
cancer treatment, yet its efficacy is hindered by both short-term and long-term cardiotoxicity …

Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide
adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is …

Background Taurine, an amino acid abundantly found in the brain and other tissues, has
potential neuroprotective properties. Alzheimer's disease (AD) is a commonly occurring type …

Abstract Sepsis-induced cardiomyopathy (SIC), caused by a dysregulated host response to
infection, is a major contributor to high mortality. Angiotensin-converting enzyme 2 (ACE2), a …

Kawasaki disease (KD), an acute exanthematous febrile pediatric illness involving systemic
non-specific inflammatory reactions in small-and medium-sized arteries, poses a significant …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important transcriptional regulator that
plays a protective role against various cardiovascular diseases. Omaveloxolone is a newly …

Sirtuins belong to the class III histone deacetylases and possess nicotinamide adenine
dinucleotide-dependent deacetylase activity. They are involved in the regulation of multiple …

Corneal endothelium is mostly sensitive to oxidative pressure and mitochondrial
dysfunction. However, the oxidative-antioxidant mechanism of corneal endothelial cells …

Cardiovascular diseases (CVDs) are the leading cause of deaths among adult population in
China, whose incidence and mortality rates continue rising with a trend towards younger …