Memory loss in Alzheimer's disease

H Jahn - Dialogues in clinical neuroscience, 2013 - Taylor & Francis
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's
disease (AD) and by their caretakers. Working memory and long-term declarative memory …

The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline

HIL Jacobs, DA Hopkins, HC Mayrhofer, E Bruner… - Brain, 2018 - academic.oup.com
The cerebellum has long been regarded as essential only for the coordination of voluntary
motor activity and motor learning. Anatomical, clinical and neuroimaging studies have led to …

Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

C Yin, P Imms, M Cheng, A Amgalan… - Proceedings of the …, 2023 - National Acad Sciences
The gap between chronological age (CA) and biological brain age, as estimated from
magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging …

[HTML][HTML] A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

JL Del-Aguila, Z Li, U Dube… - Alzheimer's research & …, 2019 - Springer
Background Alzheimer's disease (AD) is the most common form of dementia. This
neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting …

High‐order resting‐state functional connectivity network for MCI classification

X Chen, H Zhang, Y Gao, CY Wee, G Li… - Human brain …, 2016 - Wiley Online Library
Brain functional connectivity (FC) network, estimated with resting‐state functional magnetic
resonance imaging (RS‐fMRI) technique, has emerged as a promising approach for …

Understanding the multidimensional cognitive deficits of logopenic variant primary progressive aphasia

S Ramanan, M Irish, K Patterson, JB Rowe… - Brain, 2022 - academic.oup.com
The logopenic variant of primary progressive aphasia is characterized by early deficits in
language production and phonological short-term memory, attributed to left-lateralized …

[HTML][HTML] The neuroprotective effects of bilingualism upon the inferior parietal lobule: a structural neuroimaging study in aging Chinese bilinguals

J Abutalebi, M Canini, PA Della Rosa, DW Green… - Journal of …, 2015 - Elsevier
It is a timely issue to understand the impact of bilingualism upon brain structure in healthy
aging and upon cognitive decline given evidence of its neuroprotective effects. Plastic …

Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community

AM Brickman, FA Provenzano, J Muraskin… - Archives of …, 2012 - jamanetwork.com
Background New-onset Alzheimer disease (AD) is often attributed to degenerative changes
in the hippocampus. However, the contribution of regionally distributed small vessel …

[HTML][HTML] Can visuospatial measures improve the diagnosis of Alzheimer's disease?

S Salimi, M Irish, D Foxe, JR Hodges, O Piguet… - Alzheimer's & Dementia …, 2018 - Elsevier
Introduction Overlapping and evolving symptoms lead to ambiguity in the diagnosis of
dementia. Visuospatial function relies on parietal lobe function, which may be affected in the …

Deficits in spontaneous cognition as an early marker of Alzheimer's disease

L Kvavilashvili, A Niedźwieńska, SJ Gilbert… - Trends in Cognitive …, 2020 - cell.com
In the absence of a pharmacological cure, finding the most sensitive early cognitive markers
of Alzheimer's disease (AD) is becoming increasingly important. In this article we review …