Bariatric surgery is a powerful therapy for type 2 diabetes in patients with obesity. The
mechanism of insulin sensitization by surgery has been extensively investigated in weight …

Among civilization diseases, the number of individuals suffering from type 2 diabetes
(T2DM) is expected to increase to more than a billion in less than 20 years, which is …

Cofactors interacting with PPARγ can regulate adipogenesis and adipocyte metabolism by
modulating the transcriptional activity and selectivity of PPARγ signaling. ZFP407 was …

Background In spite of new treatments, the incidence of type 2 diabetes (T2D) and its
morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other …

Background The association of prediabetes (Pre-DM) regression and progression with
visceral adiposity index (VAI) and adipose tissue dysfunction (ATD) remains to be …

Leptin is expressed in white adipocytes, but not in brown adipocytes. Circulating levels of
leptin are determined by the endocrine activity of white adipose tissues. Leptin expression …

Type 2 diabetes mellitus (T2DM), the main type of diabetes, is a common chronic metabolic
disease and a serious health concern worldwide. The aim of this study was to investigate the …

During inguinal adipose tissue (iWAT) ontogenesis, beige adipocytes spontaneously appear
between postnatal 10 (P10) and P20 and their ablation impairs iWAT browning capacity in …

Adipose organ, historically known as specialized lipid-handling tissue serving as the long-
term fat depot, is now appreciated as the largest endocrine organ composed of two main …

Background The prevalence of diabetes has risen fast with a considerable weighted
prevalence of undiagnosed diabetes or uncontrolled diabetes. Then it becomes more …