Dural immune cells, CGRP, and migraine

LK Balcziak, AF Russo - Frontiers in neurology, 2022 - frontiersin.org
Migraine is the most common neurological disorder in the world, affecting 12% of the
population. Migraine involves the central nervous system, trigeminal nerves and meninges …

Glia signaling and brain microenvironment in migraine

H Amani, A Soltani Khaboushan, GM Terwindt… - Molecular …, 2023 - Springer
Migraine is a complicated neurological disorder affecting 6% of men and 18% of women
worldwide. Various mechanisms, including neuroinflammation, oxidative stress, altered …

Migraine prevention through ketogenic diet: more than body mass composition changes

M Valente, R Garbo, F Filippi, A Antonutti… - Journal of Clinical …, 2022 - mdpi.com
The ketogenic diet (KD) is gaining attention as a preventive treatment for migraine, which is
sustained by many pre-clinical and clinical data. KD is also used for weight loss, and there is …

[HTML][HTML] Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine

A Ardizzone, AP Capra, A Repici, M Lanza… - Free Radical Biology …, 2024 - Elsevier
Migraine is one of the most common neurological illnesses, and it is characterized by
complicated neurobiology. It was confirmed the influence of inflammation and oxidative …

Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway

D Yang, Y Gao, Z Yin, X Wang, X Meng, T Zou… - Acta Pharmacologica …, 2023 - nature.com
Sensitization of central pain and inflammatory pathways play essential roles in migraine, a
primary neurobiological headache disorder. Since hypoxia-inducible factor-1α (HIF-1α) is …

IL-17 crosses the blood–brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine

H Chen, X Tang, J Li, B Hu, W Yang, M Zhan… - The Journal of …, 2022 - Springer
Background Chronic migraine places a disabling burden on patients, which is extensively
modeled by the nitroglycerin (NTG)-treated animal model. Although the NF-κB pathway is …

The vascular Na, K-ATPase: clinical implications in stroke, migraine, and hypertension

C Staehr, C Aalkjaer, VV Matchkov - Clinical Science, 2023 - portlandpress.com
In the vascular wall, the Na, K-ATPase plays an important role in the control of arterial tone.
Through cSrc signaling, it contributes to the modulation of Ca2+ sensitivity in vascular …

Primary headache disorders: From pathophysiology to neurostimulation therapies

Z Wang, X Yang, B Zhao, W Li - Heliyon, 2023 - cell.com
Primary headache disorders including migraine, cluster headache, and tension-type
headache are among the most common disabling diseases worldwide. The unclear …

A single episode of cortical spreading depolarization increases mRNA levels of proinflammatory cytokines, calcitonin gene-related peptide and pannexin-1 channels …

MN Volobueva, EM Suleymanova… - International Journal of …, 2022 - mdpi.com
Cortical spreading depolarization (CSD) is the neuronal correlate of migraine aura and the
reliable consequence of acute brain injury. The role of CSD in triggering headaches that …

Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes

Z Kaya, N Belder, M Sever-Bahcekapili… - Journal of …, 2023 - Springer
The role of high mobility group box 1 (HMGB1) in inflammation is well characterized in the
immune system and in response to tissue injury. More recently, HMGB1 was also shown to …