Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which
differentiate into myofibroblasts in response to injury or stress. Although myofibroblast …

Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

Interorganellar contacts are increasingly recognized as central to the control of cellular
behavior. These contacts, which typically involve a small fraction of the endomembrane …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Measurement of oxygen consumption is a powerful and uniquely informative experimental
technique. It can help identify mitochondrial mechanisms of action following pharmacologic …

Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid
(PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes …

Mitochondria take up Ca2+ through the mitochondrial calcium uniporter complex to regulate
energy production, cytosolic Ca2+ signalling and cell death,. In mammals, the uniporter …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …