[HTML][HTML] Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models

B Guo, C Zheng, J Cao, F Luo, H Li, S Hu… - Journal of Advanced …, 2023 - Elsevier
Introduction Parkinson's disease (PD) is common neurodegenerative disease where
oxidative stress and mitochondrial dysfunction play important roles in its progression …

The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis

P Yang, Y Liu, Z Tong, Q Huang, X Xie, S Mao… - Acta Pharmacologica …, 2024 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, and its
prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived …

[HTML][HTML] The role of cellular defense systems of ferroptosis in Parkinson's disease and Alzheimer's disease

J Chu, J Li, L Sun, J Wei - International Journal of Molecular Sciences, 2023 - mdpi.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common rapidly
developing neurodegenerative diseases that lead to serious health and socio-economic …

[HTML][HTML] Recent research trends in Neuroinflammatory and neurodegenerative disorders

J Cohen, A Mathew, KD Dourvetakis… - Cells, 2024 - mdpi.com
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD),
Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis …

The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease

AR Hicks, RH Reynolds, B O'Callaghan, S García-Ruiz… - Brain, 2023 - academic.oup.com
Genetic variants conferring risks for Parkinson's disease have been highlighted through
genome-wide association studies, yet exploration of their specific disease mechanisms is …

Antagonism of β-arrestins in IL-4–driven microglia reactivity via the Samd4/mTOR/OXPHOS axis in Parkinson's disease

J Liu, Y Liang, Q Meng, J Chen, J Ma, H Zhu, L Cai… - Science …, 2024 - science.org
Interleukin-4 (IL-4)–exposed microglia acquire neuroprotective properties, but their functions
and regulation in Parkinson's disease (PD) are poorly understood. In this study, we …

[HTML][HTML] The Role of Exercise in Maintaining Mitochondrial Proteostasis in Parkinson's Disease

J Li, Y Xu, T Liu, Y Xu, X Zhao, J Wei - International Journal of Molecular …, 2023 - mdpi.com
Parkinson's disease (PD) is the second most common rapidly progressive
neurodegenerative disease and has serious health and socio-economic consequences …

[HTML][HTML] Biomarkers for Managing Neurodegenerative Diseases

L Cheslow, AE Snook, SA Waldman - Biomolecules, 2024 - mdpi.com
Neurological disorders are the leading cause of cognitive and physical disability worldwide,
affecting 15% of the global population. Due to the demographics of aging, the prevalence of …

Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease

H Wang, D He, Z Li, X Gao, S Yang, M Cui, B Ye… - Chemico-Biological …, 2023 - Elsevier
Neuronal apoptosis and neuroinflammation are key factors involved in the pathological
changes of Parkinson's disease (PD). Sophoricoside (SOP) has shown anti-inflammatory …

[HTML][HTML] Melatonin derivative 6a as a PARP-1 inhibitor for the treatment of Parkinson's disease

QW Ma, RT Han, ZJ Wu, JJ Zhou, MT Chen… - Frontiers in …, 2024 - frontiersin.org
Both continuous oxidative stress and poly (ADP-ribose) polymerase 1 (PARP-1) activation
occur in neurodegenerative diseases such as Parkinson's disease. PARP-1 inhibition can …