In the epithelium of the rodent vagina proliferation and differentiation are tightly regulated by
ovarian hormones. Estrogens stimulate proliferation and squamous differentiation, whereas …

Retinoids are powerful regulators of epidermal cell growth and differentiation and are widely
used in the prevention and treatment of skin disorders and cancers in humans. Since many …

Expression of the cell adhesion molecules E‐cadherin, P‐cadherin and α6β4 integrin and of
the keratin K13 has been analyzed in chemically induced benign skin papillomas with …

Azido-2′, 3′-dideoxythymidine (AZT, Retrovir, zidovudine), a nucleoside analogue
currently used in the therapy of acquired immunodeficiency syndrome, induces papillomas …

The sensitivity of outbred SENCAR mice and inbred SENCAR (SSIN) mice to multistage
carcinogenesis was studied. Tumors were induced using either 7, 12-dimethylbenz [α] …

Eight canine tumors originating from specific glandular structures in the anal region, as well
as metastatic tumor tissue of two of these cases (case Nos. 7, 8), were …

A significant role for mouse chromosome 7 abnormalities during chemically induced skin
carcinogenesis has been advanced based on previous cytogenetic and molecular studies …

Human head and neck squamous cell carcinogenesis (SCC) is a common malignancy that
appears to be related to continuous exposure to putative carcinogens or promoters such as …

The Syrian golden hamster cheek pouch carcinogenesis model is probably the best-known
animal system for studying events involved in the development of premalignancy and …

The mouse skin carcinogenesis model is one of the oldest systems for the study of chemical
carcinogenesis and has been extensively used for studies of genetic toxicology and …