Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role
in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets …

The histamine H3 receptor (H3R) is an important modulator of numerous central control
mechanisms. Novel lead optimizations for H3R antagonists/inverse agonists involved …

Heterocycles are very important functional groups, especially in medicinal chemistry. They
are not only pivotal in the synthesis of drugs, but also form part of the structure of a diversity …

Nischarin was reported to be a tumor suppressor that plays a critical role in breast cancer
initiation and progression, and a positive prognostic marker in breast, ovarian and lung …

Anti-cancer therapy based on the repeated administration of oxaliplatin is limited by the
development of a disabling neuropathic syndrome with detrimental effects on the patient's …

New 2-aryliminopyrrolidines (1–18) were synthesized and tested for their binding properties
on I1 imidazoline receptors vs α2-adrenergic receptors and their blood pressure effects after …

DABCO-catalyzed [3 + 2] annulation of sulfamate-derived cyclic imines with isocyanoacetates:
synthesis of sulfamate-fused 2-imidazoline - Organic & Biomolecular Chemistry (RSC …

Pharmacological studies have suggested that I1-imidazoline receptors are involved in the
regulation of cardiovascular function and that selective I1-agonists, devoid of the side effects …

Imidazoline I 2 receptors are involved in pain modulation and psychiatric disorders and its
ligands may represent a new therapeutic strategy against pain and depression. In particular …

Monoamine oxidases are the crucial drug targets for the treatment of neurodegenerative
disorders like depression, Parkinson's disease, and Alzheimer's disease. The enzymes …