Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

Pyroptosis, apoptosis and necroptosis are the most genetically well-defined programmed
cell death (PCD) pathways, and they are intricately involved in both homeostasis and …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming
fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome …

Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic
Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ …

Programmed cell death has a vital role in embryonic development and tissue homeostasis.
Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis …

Programmed cell death is regulated by evolutionarily conserved pathways that play critical
roles in development and the immune response. A newly recognized pathway for …

Cell death is central to development, organismal homeostasis, and immune responses. The
cell death field has experienced tremendous progress by delineating the molecular …