AU-rich elements: characterization and importance in mRNA degradation

CYA Chen, AB Shyu - Trends in biochemical sciences, 1995 - cell.com
Adenylate/uridylate-rich elements (AREs) are found in the 3′ untranslated region (UTR) of
many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription …

The reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive and compulsive behaviors

K Blum, ER Braverman, JM Holder… - … of psychoactive drugs, 2000 - Taylor & Francis
The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated
in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain …

[PDF][PDF] RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay

Y Yang, L Wang, X Han, WL Yang, M Zhang, HL Ma… - Molecular cell, 2019 - cell.com
The maternal-to-zygotic transition (MZT) is a conserved and fundamental process during
which the maternal environment is converted to an environment of embryonic-driven …

The cap and poly (A) tail function synergistically to regulate mRNA translational efficiency.

DR Gallie - Genes & development, 1991 - genesdev.cshlp.org
The cap structure and the poly (A) tail are important regulatory determinants in establishing
the translational efficiency of a messenger RNA. Although the mechanism by which either …

Serum amyloid A, the major vertebrate acute‐phase reactant

CM Uhlar, AS Whitehead - European journal of biochemistry, 1999 - Wiley Online Library
The serum amyloid A (SAA) family comprises a number of differentially expressed
apolipoproteins, acute‐phase SAAs (A‐SAAs) and constitutive SAAs (C‐SAAs). A‐SAAs are …

Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
46147671&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

mRNA stability in mammalian cells

J Ross - Microbiological reviews, 1995 - Am Soc Microbiol
This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49447811&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Regulation of mRNA stability in mammalian cells

J Guhaniyogi, G Brewer - Gene, 2001 - Elsevier
The regulation of mRNA decay is a major control point in gene expression. The stability of a
particular mRNA is controlled by specific interactions between its structural elements and …

A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

CJ Decker, R Parker - Genes & development, 1993 - genesdev.cshlp.org
To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …