Mechanisms of mRNA degradation in eukaryotes
CJ Decker, R Parker - Trends in biochemical sciences, 1994 - cell.com
DIFFERENCES IN degradation rates among messenger RNAs (mRNAs) contribute
significantly to the control of gene expression in eukaryotes. In this review we will focus on …
significantly to the control of gene expression in eukaryotes. In this review we will focus on …
Split dose administration
A De Fougerolles, SM Elbashir - US Patent 9,186,372, 2015 - Google Patents
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Engineered nucleic acids and methods of use thereof
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Modified polynucleotides for the production of proteins associated with blood and lymphatic disorders
T Chakraborty, A De Fougerolles - US Patent 9,233,141, 2016 - Google Patents
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Regulation of poly (A)-binding protein through PABP-interacting proteins
MC Derry, A Yanagiya, Y Martineau… - Cold Spring Harbor …, 2006 - symposium.cshlp.org
Translation initiation requires the participation of eukaryotic translation initiation factors
(eIFs). The poly (A)-binding protein (PABP) is thought to stimulate translation by promoting …
(eIFs). The poly (A)-binding protein (PABP) is thought to stimulate translation by promoting …
The role of poly (A) in the translation and stability of mRNA
A Sachs - Current opinion in cell biology, 1990 - Elsevier
Twenty years have passed since the discovery of a poly (A) tail at the 3'end of eukaryotic
mRNA (Kates, COM Spring Harbor Sjmp Quant Biol 1970, 38: 74% 752, Lim and Canellakis …
mRNA (Kates, COM Spring Harbor Sjmp Quant Biol 1970, 38: 74% 752, Lim and Canellakis …
Engineered nucleic acids and methods of use thereof
A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, eg
guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as …
guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as …
Modified polynucleotides encoding apoptosis inducing factor 1
T Chakraborty, A De Fougerolles - US Patent 9,301,993, 2016 - Google Patents
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The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits protein synthesis at the initiation stage
MP Nekrasov, MP Ivshina, KG Chernov… - Journal of Biological …, 2003 - ASBMB
The cytoplasmic messenger ribonucleoprotein particles of mammalian somatic cells contain
the protein YB-1, also called p50, as a major core component. YB-1 is multifunctional and …
the protein YB-1, also called p50, as a major core component. YB-1 is multifunctional and …
Tales of poly (A): a review
D Munroe, A Jacobson - Gene, 1990 - Elsevier
Until recently, evidence to support a translational role for the 3′-poly (A) tract of eukaryotic
mRNAs has been mostly indirect, including: a correlation between the adenylation status of …
mRNAs has been mostly indirect, including: a correlation between the adenylation status of …