[HTML][HTML] Polymeric micellar systems—a special emphasis on “smart” drug delivery

I Negut, B Bita - Pharmaceutics, 2023 - mdpi.com
Concurrent developments in anticancer nanotechnological treatments have been observed
as the burden of cancer increases every year. The 21st century has seen a transformation in …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Evaluation of the Cytotoxic Activity and Anti-Migratory Effect of Berberine–Phytantriol Liquid Crystalline Nanoparticle Formulation on Non-Small-Cell Lung Cancer In …

AM Alnuqaydan, AG Almutary, M Azam, B Manandhar… - Pharmaceutics, 2022 - mdpi.com
Non-small-cell lung cancer (NSCLC) is the most common form of lung cancer, which is a
leading cause of cancer-related deaths worldwide. Berberine is an isoquinoline alkaloid that …

Inhalation drug delivery in combating pulmonary infections: Advances and challenges

P Kumbhar, J Kaur, G De Rubis, KR Paudel… - Journal of Drug Delivery …, 2023 - Elsevier
Pulmonary infections (PIs) are contributing as a significant cause of mortality across the
world. The clinical applications of a variety of therapeutics approved for PIs have been …

18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration

KR Paudel, MSB Mohamad, G De Rubis… - Journal of Drug Delivery …, 2024 - Elsevier
Conventional treatment methods to treat lung cancer include radiation therapy,
chemotherapy, and immunotherapy. However, they cause severe adverse effects and …

Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases

AB Saeid, VK Patel, S Mehndiratta, R Rajput… - Food Bioscience, 2023 - Elsevier
Lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung
cancer are prevalent worldwide, with high mortality rates. There are many pathways …

Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma

VSRR Allam, KR Paudel, G Gupta, SK Singh… - … Science and Pollution …, 2022 - Springer
Asthma is a chronic inflammatory disease primarily characterized by inflammation and
reversible bronchoconstriction. It is currently one of the leading causes of morbidity and …

Berberine-loaded engineered nanoparticles attenuate TGF-β-induced remodelling in human bronchial epithelial cells

G De Rubis, KR Paudel, G Liu, V Agarwal… - Toxicology in Vitro, 2023 - Elsevier
Airway remodelling occurs in chronic respiratory diseases (CRDs) such as asthma and
chronic obstructive pulmonary disease (COPD). It is characterized by aberrant activation of …

Chitosan modified 5-fluorouracil nanostructured lipid carriers for treatment of diabetic retinopathy in rats: A new dimension to an anticancer drug

DS Sharma, S Wadhwa, M Gulati, B Kumar… - International journal of …, 2023 - Elsevier
Diabetic retinopathy (DR) is one of the chronic complications of diabetes. It includes retinal
blood vessels' damage. If untreated, it leads to loss of vision. The existing treatment …