The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

[HTML][HTML] Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy

C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …

Immune and inflammatory mechanisms in hypertension

TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

Salt sensitivity: causes, consequences, and recent advances

MA Bailey, N Dhaun - Hypertension, 2024 - Am Heart Assoc
Salt (sodium chloride) is an essential nutrient required to maintain physiological functions.
However, for most people, daily salt intake far exceeds their physiological need and is …

[HTML][HTML] Novel mechanisms of salt-sensitive hypertension

L Vogt, FZ Marques, T Fujita, EJ Hoorn, AHJ Danser - Kidney International, 2023 - Elsevier
A high dietary sodium-consumption level is considered the most important lifestyle factor that
can be modified to help prevent an increase in blood pressure and the development of …

Gut-immune axis and cardiovascular risk in chronic kidney disease

F Behrens, H Bartolomaeus, N Wilck… - Clinical Kidney …, 2024 - academic.oup.com
Patients with chronic kidney disease (CKD) suffer from marked cardiovascular morbidity and
mortality, so lowering the cardiovascular risk is paramount to improve quality of life and …

Influence of angiotensin II on the gut microbiome: modest effects in comparison to experimental factors

RR Muralitharan, ME Nakai, M Snelson… - Cardiovascular …, 2024 - academic.oup.com
Aims Animal models are regularly used to test the role of the gut microbiome in
hypertension. Small-scale pre-clinical studies have investigated changes to the gut …

Brain-Splenic Immune System Interactions in Hypertension: Cellular and Molecular Mechanisms

S Perrotta, D Carnevale - Arteriosclerosis, Thrombosis, and …, 2024 - Am Heart Assoc
Hypertension represents a major worldwide cause of death and disability, and it is becoming
increasingly clear that available therapies are not sufficient to reduce the risk of major …

[HTML][HTML] Exploring a novel therapeutic strategy: the interplay between gut microbiota and high-fat diet in the pathogenesis of metabolic disorders

X Jia, Q Chen, H Wu, H Liu, C Jing, A Gong… - Frontiers in …, 2023 - frontiersin.org
In the past two decades, the rapid increase in the incidence of metabolic diseases, including
obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and …

[HTML][HTML] Changes in the gut microbiome of patients with type a aortic dissection

F Jiang, M Cai, Y Peng, S Li, B Liang, H Ni… - Frontiers in …, 2023 - frontiersin.org
Objective To investigate the characteristic changes in the gut microbiota of patients with type
A aortic dissection (AAD) and provide a theoretical basis for future microbiome-oriented …