Cancer development and its response to therapy are regulated by inflammation, which
either promotes or suppresses tumor progression, potentially displaying opposing effects on …

Inflammation is strictly associated with cancer and plays a key role in tumor development
and progression. Several epidemiological studies have demonstrated that inflammation can …

The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Bicyclic nitroimidazoles, including PA-824, are exciting candidates for the treatment of
tuberculosis. These prodrugs require intracellular activation for their biological function. We …

Inflammation is closely linked to cancer, and many anti-cancer agents are also used to treat
inflammatory diseases, such as rheumatoid arthritis. Moreover, chronic inflammation …

For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP
(cGMP) have been recognized as important signaling molecules within cells. Under normal …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is globally
known as one of the most important human pathogens. Mtb is estimated to infect nearly one …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

There are numerous gaseous substances that can act as signaling molecules, but the best
characterized of these are nitric oxide, hydrogen sulfide and carbon monoxide. Each has …

S-nitrosylation is a selective and reversible post-translational modification of protein thiols by
nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These …