[HTML][HTML] Cryptococcus neoformans Infection in the Central Nervous System: The Battle between Host and Pathogen

Y Chen, ZW Shi, AB Strickland, M Shi - Journal of Fungi, 2022 - mdpi.com
Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

Cryptococcal interactions with the host immune system

K Voelz, RC May - Eukaryotic cell, 2010 - Am Soc Microbiol
Opportunistic pathogens have become of increasing medical importance over the last
decade due to the AIDS pandemic. Not only is cryptococcosis the fourth-most-common fatal …

Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

K Voelz, DA Lammas, RC May - Infection and immunity, 2009 - Am Soc Microbiol
The pathogenic yeast Cryptococcus neoformans and C. gattii commonly cause severe
infections of the central nervous system in patients with impaired immunity but also …

The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal …

JN Jarvis, JP Casazza, HH Stone… - The Journal of …, 2013 - academic.oup.com
Background. Correlates of immune protection in patients with human immunodeficiency
virus (HIV)–associated cryptococcal meningitis are poorly defined. A clearer understanding …

Virulence in Cryptococcus species

H Ma, RC May - Advances in applied microbiology, 2009 - Elsevier
Cryptococcus neoformans and Cryptococcus gattii are the cause of life-threatening
meningoencephalitis in immunocompromised and immunocompetent individuals …

Harnessing the immune response to fungal pathogens for vaccine development

A Rivera, J Lodge, C Xue - Annual review of microbiology, 2022 - annualreviews.org
Invasive fungal infections are emerging diseases that kill over 1.5 million people per year
worldwide. With the increase of immunocompromised populations, the incidence of invasive …

IL‐12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans

K Kawakami, M Tohyama, Q Xie… - Clinical & Experimental …, 1996 - Wiley Online Library
We examined the role of IL‐12 in host resistance to Cryptococcus neoformans using a
murine model of pulmonary and disseminated infection. In this model, mice were infected …

T cells cooperate with passive antibody to modify Cryptococcus neoformans infection in mice

RR Yuan, A Casadevall, J Oh… - Proceedings of the …, 1997 - National Acad Sciences
Cryptococcus neoformans is an encapsulated fungus that is a major cause of meningitis in
patients with AIDS. In immunocompetent mice, administration of IgG1 mAb protects against …

Immunologic mechanisms of fingolimod and the role of immunosenescence in the risk of cryptococcal infection: a case report and review of literature

E Grebenciucova, AT Reder, JT Bernard - Multiple sclerosis and related …, 2016 - Elsevier
Background Fingolimod is a disease-modifying agent used in the treatment of
relapsing/remitting multiple sclerosis. In MS clinical studies, the overall rate of infections in …

Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans

DO Beenhouwer, S Shapiro, M Feldmesser… - Infection and …, 2001 - Am Soc Microbiol
Variable-region-identical mouse immunoglobulin G1 (IgG1), IgG2b, and IgG2a monoclonal
antibodies to the capsular polysaccharide of Cryptococcus neoformans prolong the lives of …