The human fungal pathogens Cryptococcus neoformans and C. gattii cause life-threatening
infections of the central nervous system. One of the major characteristics of cryptococcal …

We investigated the effects of G-CSF in a granulocytopenic mouse model of Pseudomonas
aeruginosa lung infection. The model was prepared by intratracheal instillation of the …

The influence of the 6kDa early-secreted antigenic target (ESAT-6) of Mycobacterium
tuberculosis on macrophage activation was investigated using J774 macrophage cell line …

The aim of this study was to investigate the changes of Th1/Th2 cytokines in
immunocompetent patients with pulmonary cryptococcosis (PC). Twenty immunocompetent …

The results reported herein show that T cells responding to encapsulated Cryptococcus
neoformans cells had reduced expression of interleukin‐12 receptor β2 (IL‐12Rβ2) in …

The pathogenic fungi Cryptococcus neoformans and Cryptococcus gattii are two of the main
causes of life-threatening meningoencephalitis in immunocompromised and …

The encapsulated fungal pathogen Cryptococcus neoformans is a significant agent of life-
threatening infections, particularly in people with suppressed cell-mediated immunity. The …

There is a limited understanding of the population pharmacokinetics (PK) and
pharmacodynamics (PD) of amphotericin B deoxycholate (DAmB) for cryptococcal …

Cryptococcus neoformans is one of the leading causes of invasive fungal infection in
humans worldwide. C. neoformans uses macrophages as a proliferative niche to increase …

OBJECTIVE: To provide a basic understanding of the mechanisms of host defense to
pathogenic fungi. This will help physicians understand why some patients are predisposed …