The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Directed differentiation of human pluripotent stem cells to kidney organoids brings the
prospect of drug screening, disease modelling and the generation of tissue for renal …

Distinct from the traditional diagnostic/prognostic biomarker (adopted as the indicator of
disease state/process), the therapeutic biomarker (ThMAR) has emerged to be very crucial …

Drug-induced acute kidney injury (AKI) with a high morbidity and mortality is poorly
diagnosed in hospitals and deficiently evaluated in drug discovery. Here, we report the …

Acute kidney injury (AKI) is a prevalent and lethal adverse event that severely affects cancer
patients receiving chemotherapy. It is correlated with the collateral damage to renal cells …

T cell bispecific antibodies (TCBs) are the focus of intense development for cancer
immunotherapy. Recently, peptide-MHC (major histocompatibility complex)-targeted TCBs …

Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a
basal state after tubular injury. When injury is overwhelming or repetitive, however, that …

Acute kidney injury (AKI) can lead to loss of kidney function and a substantial increase in
mortality. The burst of reactive oxygen species (ROS) plays a key role in the pathological …