Organ-on-chips (OOCs) are microfluidic devices used for creating physiological organ
biomimetic systems. OOC technology brings numerous advantages in the current landscape …

The development of human cell-based systems to replace the use of rodents or the two-
dimensional culture of cells for studying nephrotoxicity is urgently needed. Human urine …

The kidneys are often involved in adverse effects and toxicity caused by exposure to foreign
compounds, chemicals, and drugs. Early predictions of these influences are essential to …

Objectives Antibacterial drug discovery activities are essential for filling clinical pipelines
with promising clinical candidates. Little information is available about the challenges and …

Microphysiological systems are an emerging area of in vitro drug development, and their
independent evaluation is important for wide adoption and use. The primary goal of this …

Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various
diseases and it accounts for around 25% of serious side-effects reported after drug …

Drug‐induced renal failure (DIRF) poses a serious medical complication with high mortality
risk. However, early diagnosis or prognosis of DIRF remain challenging, as current methods …

Background Kidney disease modeling and assessment of drug-induced kidney injury can be
advanced using three-dimensional (3D) microfluidic models that recapitulate in vivo …

Cisplatin is one of the most effective antitumor agents, but its clinical use is highly limited by
its severe side effects, especially nephrotoxicity. Recently, the active form of gasdermin D …

Ethnopharmacological relevance The prevalence of kidney disease has increased rapidly in
recent years and has emerged as one of the leading causes of mortality worldwide. Natural …