[HTML][HTML] Currently Used Methods to Evaluate the Efficacy of Therapeutic Drugs and Kidney Safety

HJ Huang, CL Chou, TT Sandar, WC Liu, HC Yang… - Biomolecules, 2023 - mdpi.com
Kidney diseases with kidney failure or damage, such as chronic kidney disease (CKD) and
acute kidney injury (AKI), are common clinical problems worldwide and have rapidly …

[HTML][HTML] Impaired regeneration potential in urinary stem cells diagnosed from the patients with diabetic nephropathy

G Xiong, W Tang, D Zhang, D He, G Wei, A Atala… - Theranostics, 2019 - ncbi.nlm.nih.gov
Stem cells present in urine possess regenerative capacity to repair kidney injury. However,
the unique characteristics of urinary stem cells (USC) from patients with diabetic …

Nephrotoxicity induced by natural compounds from herbal medicines–a challenge for clinical application

J Rao, T Peng, N Li, Y Wang, C Yan… - Critical reviews in …, 2022 - Taylor & Francis
Herbal medicines (HMs) have long been considered safe and effective without serious toxic
and side effects. With the continuous use of HMs, more and more attention has been paid to …

Recent advances in engineered nanomaterials for acute kidney injury theranostics

L Wang, Y Zhang, Y Li, J Chen, W Lin - Nano Research, 2021 - Springer
Acute kidney injury (AKI), has become the focus of increasing attention due to its high risk of
death. The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue …

[HTML][HTML] Precision nephrotoxicity testing using 3D in vitro models

P Yu, H Zhu, CC Bosholm, D Beiner, Z Duan… - Cell & Bioscience, 2023 - Springer
Nephrotoxicity is a significant concern during the development of new drugs or when
assessing the safety of chemicals in consumer products. Traditional methods for testing …

[HTML][HTML] Guidelines for manufacturing and application of organoids: kidney

HM Kang, DS Kim, YK Kim, K Shin… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Recent advancements in organoid technology have led to a vigorous movement towards
utilizing it as a substitute for animal experiments. Organoid technology offers versatile …

[HTML][HTML] In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes

S Abyar, AA Khandar, R Salehi… - Scientific reports, 2019 - nature.com
Complexes based on heavy metals have great potential for the treatment of a wide variety of
cancers but their use is often limited due to toxic side effects. Here we describe the synthesis …

Automation of organoid cultures: Current protocols and applications

A Louey, D Hernández, A Pébay… - … the Science of Drug …, 2021 - journals.sagepub.com
Organoids are three-dimensional, functional structures that mimic in vivo organs. They offer
new opportunities for the modeling of cancer and infectious and rare hereditary diseases …

[HTML][HTML] Drugs commonly applied to kidney patients may compromise renal tubular uremic toxins excretion

SM Mihaila, J Faria, MFJ Stefens, D Stamatialis… - Toxins, 2020 - mdpi.com
In chronic kidney disease (CKD), the secretion of uremic toxins is compromised leading to
their accumulation in blood, which contributes to uremic complications, in particular …

Ultrasmall Nanodots with Dual Anti‐Ferropototic Effect for Acute Kidney Injury Therapy

F Zeng, Y Qin, S Nijiati, Y Liu, J Ye, H Shen… - Advanced …, 2024 - Wiley Online Library
Ferroptosis is known to mediate the pathogenesis of chemotherapeutic drug‐induced acute
kidney injury (AKI); however, leveraging the benefits of ferroptosis‐based treatments for …