The proinflammatory property of cisplatin is potentially destructive and contributes to the
pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of …

Abstract Traditional two-dimensional (2D) cell culture employed for centuries is extensively
used in toxicological studies. There is no doubt that 2D cell culture has made significant …

The brevicidines represent a novel class of nonribosomal antimicrobial peptides that
possess remarkable potency and selectivity toward highly problematic and resistant Gram …

Proximal tubule (PT) cells maintain a high-capacity apical endocytic pathway to recover
essentially all proteins that escape the glomerular filtration barrier. The multi ligand …

Real-time and non-invasive assessment of tissue health is crucial for maximizing the
potential of microphysiological systems (MPS) for drug-induced nephrotoxicity screening …

Podocytes are of key interest for the prediction of nephrotoxicity as they are especially
sensitive to toxic insults due to their central role in the glomerular filtration apparatus …

High-throughput drug screening is crucial for advancing healthcare through drug discovery.
However, a significant limitation arises from available in vitro models using conventional 2D …

Proximal tubule epithelial cells are the main driver of renal transport and secretion of
xenobiotics, making them susceptible to drug-induced kidney injury. Cell-based assays are …

There have been intensive efforts to identify in vivo biomarkers that can be used to monitor
drug-induced kidney damage before significant impairment occurs. Kidney injury molecule …

Identifying the key toxic players within an in-vivo toxic syndrome is crucial to develop
targeted therapies. Here, we established a novel method that characterizes the effect of …