Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

The liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering
the body via the gut, the liver appears designed to detect, capture, and clear bacteria …

Abstract Background and Aims Immunotherapy with programmed cell death 1 (PD‐
1)/programmed death ligand 1 (PD‐L1) blockade has shown low response rates in liver …

Background Telomere dysfunction is associated with idiopathic pulmonary fibrosis (IPF) and
worse outcomes following lung transplantation. Telomere dysfunction may impair immunity …

Prolidase deficiency (PD) is a multisystem disorder caused by mutations in the PEPD gene,
which encodes a ubiquitously expressed metallopeptidase essential for the hydrolysis of …

Although double positive CD4+ CD8+ T (DPT) cells has been reported to be involved in
some diseases, their trajectory and function as associated with liver transplantation (LT) …

Organ transplantation stands as a pivotal achievement in modern medicine, offering hope to
individuals with end-stage organ diseases. Advancements in immunology led to improved …

Allogeneic CD8+ T cells are prominently involved in allograft rejection, but how their effector
differentiation and function are regulated at a transcriptional level is not fully understood …

Abstract Tolerance is the Holy Grail of solid organ transplantation (SOT) and remains its
primary challenge since its inception. In this topic, the seminal contributions of Thomas …

Combined heart–liver transplantation (CHLT) is indicated for patients with concomitant end‐
stage heart and liver disease or patients with amyloid heart disease where liver …