Cell replacement in adult organs can be achieved through stem cell differentiation or the
replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

Seeking to assess the representative and instructive value of an engineered mouse model
of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled …

The biliary tree is composed of intrahepatic and extrahepatic bile ducts, lined by mature
epithelial cells called cholangiocytes, and contains peribiliary glands deep within the duct …

Stem/progenitors for liver, biliary tree, and pancreas exist at early stages of development in
the definitive ventral endoderm forming the foregut. In humans, they persist postnatally as …

Neurons have their own systems for regulating RNA. Several multigene families encode
RNA binding proteins (RNABPs) that are uniquely expressed in neurons, including the well …

Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-
cells in the pancreas, resulting in failure of blood glucose regulation and devastating …

Pancreatic Ductal Adenocarcinoma (PDAC) is the fourth most common cause of cancer-
related death and is the most lethal of common malignancies with a five-year survival rate …

BACKGROUND & AIMS: There have been conflicting results on a cell of origin in pancreatic
regeneration. These discrepancies predominantly stem from lack of specific markers for the …