Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of
certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non …

Flaviviruses such as dengue (DENV), yellow fever (YFV), West Nile (WNV), and Zika (ZIKV)
are human pathogens of global significance. In particular, DENV causes the most prevalent …

The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including
Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models …

Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction,
spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental …

CD8+ T cells may play a dual role in protection against and pathogenesis of flaviviruses,
including Zika virus (ZIKV). We evaluated the CD8+ T cell response in ZIKV-infected …

The vector-borne flaviviruses cause severe disease in humans on every inhabited continent
on earth. Their transmission by arthropods, particularly mosquitoes, facilitates large …

Innate immunity is the first line of defense against invading pathogens. Rapid and efficient
detection of pathogen-associated molecular patterns via pattern-recognition receptors is …

Although the outcome of flavivirus infection can vary from asymptomatic to lethal,
environmental factors modulating disease severity are poorly defined. Here, we observed …

In the context of the only available vaccine (DENGVAXIA) that was marketed in several
countries, but poses higher risks to unexposed individuals, the development of antivirals for …

A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated
with microcephaly and other congenital malformations in infants as well as Guillain-Barre …