Congenital hearing loss (hearing loss that is present at birth) is one of the most prevalent
chronic conditions in children. In the majority of developed countries, neonatal hearing …

Gene therapy focuses on genetic modification to produce therapeutic effects or treat
diseases by repairing or reconstructing genetic material, thus being expected to be the most …

Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the
sensory cells of the inner ear, dysfunction of its lateral wall, axonal retraction of type 1C …

Hearing loss is the most common sensory disorder. While gene therapy has emerged as a
promising treatment of inherited diseases like hearing loss, it is dependent on the …

In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to
transduce different stimuli: sound and acceleration. Each individual sensory epithelium is …

Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …

Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to
contribute to speech discrimination and intelligibility deficits in people with normal …

Gene therapy, or the treatment of human disease using genetic material, for inner ear
dysfunction is coming of age. Recent progress in developing gene therapy treatments for …

The peripheral nervous system responds to a wide variety of sensory stimuli, a process that
requires great neuronal diversity. These diverse neurons are closely associated with glial …

Phagocytic activity of glial cells is essential for proper nervous system sculpting,
maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and …