Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

Chili peppers produce the pungent vanilloid compound capsaicin, which offers protection
from predatory mammals. Birds are indifferent to the pain-producing effects of capsaicin and …

Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons,
and thereby produces severe pain. A nonselective cation channel activated by capsaicin …

A large body of evidence now exists to substantiate that the endocannabinoid, anandamide,
activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a …

There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G
proteins. CB1 receptors exist primarily on central and peripheral neurons, one of their …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

The capsaicin (vanilloid) receptor, VR1, is a sensory neuron-specific ion channel that serves
as a polymodal detector of pain-producing chemical and physical stimuli. The response of …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

Depending on their primary structure, the 28 mammalian transient receptor potential (TRP)
cation channels identified so far can be sorted into 6 subfamilies: TRPC (“Canonical”), TRPV …