Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

The association between weight-adjusted-waist index and abdominal aortic calcification in adults aged≥ 40 years: results from NHANES 2013–2014

Z Qin, D Du, Y Li, K Chang, Q Yang, Z Zhang, R Liao… - Scientific Reports, 2022 - nature.com
The negative effects of obesity on the cardiovascular health have drawn much attention.
Weight-adjusted-waist index (WWI) has been proved to reflect weight-independent …

A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults

J Cui, Z Yang, J Wang, S Yin, Y Xiao, Y Bai… - Frontiers in …, 2023 - frontiersin.org
Background The visceral adiposity index (VAI) is regarded as a reliable indicator to assess
body fat distribution and dysfunction. Klotho protein is a hormone with anti-aging biological …

Association between dietary selenium intake and severe abdominal aortic calcification in the United States: A cross-sectional study

W Dong, X Liu, L Ma, Z Yang, C Ma - Food & Function, 2024 - pubs.rsc.org
Abdominal aortic calcification (AAC) is an important predictor of cardiovascular disease. The
purpose of the current study was to detect the association between dietary selenium intake …

Coffee consumption and abdominal aortic calcification among adults with and without hypertension, diabetes, and cardiovascular diseases

H Fan, Y Xiong, Y Huang, W Li, C Xu, X Feng… - Nutrition, Metabolism …, 2023 - Elsevier
Background and aims This study was performed to investigate the effect of coffee
consumption on abdominal aortic calcification (AAC) among adults with and without …

Association between weight change and serum anti-aging protein α-Klotho: a cross-sectional study in middle-aged and older adults

S Chen, Y Kong, N Wang, N Kang, H Chen, Z Zhang… - Scientific Reports, 2024 - nature.com
The relationship of weight change has extended to accelerated ageing, yet little is known
about the association between weight change and anti-aging protein α-Klotho. This study …

A combined circulating microRNA panel predicts the risk of vascular calcification in community-dwelling older adults with age strata differences

SY Lee, CT Chao, DS Han, CK Chiang… - Archives of Gerontology …, 2024 - Elsevier
Background Older adults have a higher risk of developing vascular calcification (VC).
Circulating miRNAs can be potential risk indicators. However, prior studies used single …

Association of serum klotho levels with different-staged vascular calcification status in patients with maintenance hemodialysis

Y Lin, J Huang, M Zhou, C Pan, A Shan, C Zhou - BMC nephrology, 2022 - Springer
Background Vascular calcification (VC) is suggested to be associated with serum klotho
levels in patients with maintenance hemodialysis (MHD), whereas there is a lack of reports …

Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013–2014

C Cai, L Wang, Q Chen, M Lin, X Pan, W Chen… - BMC Cardiovascular …, 2024 - Springer
Abstract Background Hemoglobin A1c (HbA1c), a “gold standard” for the assessment of
glycemic control, was associated with an increased risk of cardiovascular disease and …

A cross-sectional study investigating the relationship between urinary albumin creatinine ratio and abdominal aortic calcification in adults

X Xue, C Li, D Chen - Frontiers in Cardiovascular Medicine, 2024 - frontiersin.org
Introduction The presence of abdominal aortic calcification (AAC) is strongly linked to the
development of atherosclerosis and the incidence of morbidity and mortality related to …