Retinoblastoma (Rb), the most frequent malignant intraocular tumor in childhood, is caused
by mutations in the retinoblastoma gene (RB1) situated on chromosome 13q14. 2. The …

Retinoblastoma is the most common primary intraocular malignancy in children. Although
traditional chemotherapy has shown some success in retinoblastoma management, there …

Retinoblastoma is the most common intraocular malignancy in children. The treatment of this
rare disease is still challenging in developing countries due to delayed diagnosis. The …

The treatment of childhood solid cancer has markedly evolved in recent years following a
refined molecular characterization and the introduction of novel targeted drugs. On one …

Background MYCN-amplified RB1 wild-type (MYCN A RB1+/+) retinoblastoma is a rare but
clinically important subtype of retinoblastoma due to its aggressive character and relative …

Retinoblastoma Origins and Destinations | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

The neddylation inhibitor MLN4924/Pevonedistat is in clinical trials for multiple cancers.
Efficacy is generally attributed to cullin RING ligase (CRL) inhibition, but the contribution of …

Drug resistance (DR) is one of the challenges in treating retinoblastoma (Rb) that warrants
novel approaches. With the emerging evidence on the role of small extracellular vesicles …

Local chemotherapy using polymer drug delivery systems has the potential to treat some
cancers, including intraocular retinoblastoma, which is difficult to treat with systemically …

Malignant neoplasms are one of the main causes of death, especially in children, on a
global scale, despite strenuous efforts made at advancing both diagnostic and therapeutic …