Oncology drug discovery and development has always been an area facing many
challenges. Phase 1 oncology studies are typically small, open-label, sequential studies …

Retinoblastoma (RB) is a childhood retinal neoplasm and commonly treated with cytotoxic
chemotherapeutic agents. However, these therapeutic approaches often lead to diverse …

Objective To study the long-term safety and efficacy of intravitreal topotecan (IVT) against
vitreous seeds in eyes with retinoblastoma and risk factors for their recurrence. Design …

Retinoblastoma is an eye cancer that commonly affects young children. Despite significant
advances, current treatments cause side effects even when administered locally, and …

Background Retinoblastoma (RB) is a rare type of pediatric ocular cancer with difficulty in
treatment and detection owing to alterations in tumor suppressor genes and the lack of …

Purpose: Surgery, multiagent systemic chemotherapy, and radiation are used for patients
with orbital retinoblastoma but are associated with unacceptable short-and long-term toxicity …

Simple Summary This study investigates the adverse effects of selective intra-arterial
chemotherapy (SIAC) on the eyes and optic nerves of retinoblastoma patients using …

Background: This study compares the outcomes of managing retinoblastoma between
patients with unilateral and bilateral presentations. Methods: The study, conducted at the …

Background Management guidelines and corresponding survival data for patients with
recurrent retinoblastoma (RB) are lacking. This study aimed to summarize the clinical …

Background Osteosarcoma is the most common secondary malignancy among survivors of
retinoblastoma. Most previous reports on secondary malignancy of retinoblastoma included …