Topotecan (TPT) is used in the treatment of retinoblastoma, the most common malignant
intraocular tumor in children. TPT undergoes pH‐dependent hydrolysis of the lactone ring to …

Retinoblastoma (RB) is a prevalent primitive intraocular malignancy in children, particularly
in those younger than age 3 years. RB is caused by mutations in the RB1 gene. In …

Introduction: Intraocular surgeries are conventionally contraindicated for patients with active
retinoblastoma (Rb) due to the potential risk of tumor dissemination. However, surgery is …

Background: Retinoblastoma, although rare, is one of the most common intraocular
malignancies worldwide. Its prognosis has improved significantly in the past few decades …

Retinoblastoma is the most common pediatric ocular malignancy. It is triggered by a biallelic
mutation in the RB1 gene or MYCN oncogene amplification. Retinoblastomas can be …

Objectives To characterize the clinical features, treatment, and outcome of children
diagnosed with retinoblastoma (RB) at Vietnam National Cancer Hospital. Methods The …

视网膜母细胞瘤是一种最常见于儿童的原发性眼内恶性肿瘤, 其恶性程度高, 病程进展快,
预后差. 近年来, 铂类化疗药物被发现对晚期和转移性视网膜母细胞瘤具有显著的治疗效果 …

Purpose To determine the direct medical costs and cost-effectiveness of globe salvage
compared with primary enucleation in patients with advanced retinoblastoma. Methods …

目的探讨长链非编码RNA (lncRNA) 序列相似家族83 成员A-反义核糖核酸1 (FAM83AAS1)
在视网膜母细胞瘤(RB) 细胞中的作用及其潜在的分子机制. 方法体外培养RB 细胞, 将Vector …

BACKGROUND AND PURPOSE: Retinoblastoma is the most common primary intraocular
tumor in childhood. Intra-arterial chemotherapy is becoming the standard of care for both first …