In vitro dissolution and permeability testing aid the simulation of the in vivo behavior of
inhalation drug products. Although the regulatory bodies have specific guidelines for the …

Introduction Dry powder inhaler (DPI) formulations are gaining attention as universal
formulations with applications in a diverse range of drug formulations. The practical …

Tigecycline (TIG) is a broad-spectrum antibiotic that has been approved for the treatment of
a number of complicated infections, including community-acquired bacterial pneumonia …

A new modelling approach for dissolution of polydisperse powders is developed within the
framework of the classical Noyes–Whitney/Nernst–Brunner analysis. Its distinguishing …

Given the environmental compulsion to reformulate pressurised metered dose inhalers
(pMDI) using new propellants with lower global warming potential, this study investigated …

Aims Systemic pharmacokinetic (PK) studies can reflect the overall exposure of orally
inhaled drug Products (OIDPs) in the blood after inhalation into the lung and can be used to …

Abstract An inhalation-based Biopharmaceutics Classification System for pulmonary drugs
(iBCS) holds the perspective to allow for scientifically sound prediction of differences in the …

Background In development of inhaled drugs-and formulations the measured concentration
in the systemic circulation is often used as a surrogate for local dosimetry in the lungs. To …

Almost all current orally inhaled drug products (OIDPs) are for the treatment of respiratory
diseases, and many have been designed using molecular or formulation strategies to retain …

In this article, we specify for the first time a quantitative biopharmaceutics classification
system for orally inhaled drugs. To date, orally inhaled drug product developers have lacked …