Value of information (VOI) techniques can provide estimates of the expected benefits from
clinical research studies that can inform decisions about the design and priority of those …

Motivation Identification of rodent carcinogens is an important task in risk assessment of
chemicals. SAR methods were proposed to reduce the number of animal experiments. Most …

International regulatory guidelines require that new chemical entities (NCEs) be tested first
on animals (preclinical studies) for safety and efficacy before the start of clinical …

A variety of preclinical approaches have been used for assessing carcinogenic potential of
pharmaceuticals. The need for carcinogenicity assessment of a biopharmaceutical is based …

The correct prediction of human risk after exposure to chemical and physical compounds
has been a major challenge for a long time. For this, the lifetime bioassay using rats and …

The correct prediction of human risk after exposure to chemical and physical compounds
has been a major challenge for a long time. For this, the lifetime bioassay using rats and …

International regulatory guidelines require that new chemical entities (NCEs) be tested first
on animals (preclinical studies) for safety and efficacy before the start of clinical …

Toxicogenomics is defined as the “application of the knowledge of genes associated with
disease states to study the toxicology of chemical and physical agents”[1]. The simultaneous …

International regulatory guidelines require that new chemical entities (NCEs) be tested first
on animals (preclinical studies) for safety and efficacy before the start of clinical …