Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan
infections, as well as the control of human cancer. The success of therapy is being …

A range of antimicrobial peptides (AMP) exhibit activity on malaria parasites, Plasmodium
spp., in their blood or mosquito stages, or both. These peptides include a diverse array of …

Resistance to folate antagonists is caused by mutations in the dihydrofolate reductase
(DHFR) genes. These mutations affect the amino acids at positions 51, 59, 108 and 164 of …

A vaccine remains a priority in the global fight against malaria. Here, we report on a single-
center, randomized, double-blind, placebo and adjuvant-controlled, dose escalation phase …

Abstract Background The World Health Organization recommends malaria to be confirmed
by either microscopy or a rapid diagnostic test (RDT) before treatment. The correct use of …

Background Artemisinin combination therapy (ACT) is recommended as first-line treatment
for uncomplicated Plasmodium falciparum malaria, whereas chloroquine is still commonly …

Accumulating evidence displays that an abnormal deposition of amyloid beta-peptide (Aβ) is
the primary cause of the pathogenesis of Alzheimer's disease (AD). And therefore the …

Severe malaria in pregnancy is a large contributor to maternal morbidity and mortality.
Intravenous quinine has traditionally been the treatment drug of choice for severe malaria in …

We show here that crotamine, a polypeptide from the South American rattlesnake venom
with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent …

Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …